Research on CBD for All Cancer Types

Research on CBD for General Cancer

Cannabinoids – a new weapon against cancer?   2016

A user’s guide to cannabinoid therapies in oncology. 2016

Cannabis and Cannabinoids (PDQ®): Health Professional Version. 2001

Cannabidiol: State of the art and new challenges for therapeutic applications. 2017

Clinical trials of medicinal cannabis for appetite-related symptoms from advanced cancer: a survey of preferences, attitudes and beliefs among patients willing to consider participation. 2016
Cannabinoids for Symptom Management and Cancer Therapy: The Evidence.   2016

Modulation of Human Peripheral Blood Mononuclear Cell Signaling by Medicinal Cannabinoids. 2017

The Use of Medical Marijuana in Cancer. 2016

Endocannabinoid System: A Multi-Facet Therapeutic Target. 2016

Integrating cannabis into clinical cancer care. 2016

Why I chose to use cannabis. 2016

Cannabis and cancer: toward a new understanding. 2016

Cannabinoids: Medical implications. 2016

Ligands for cannabinoid receptors, promising anticancer agents. 2016
Cannabinoid-induced autophagy: Protective or death role? 2015

Phytocannabinoids for Cancer Therapeutics: Recent Updates and Future Prospects. 2015

The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids. 2015

Cannabis in cancer care. 2015

Delta(9) -tetrahydrocannabinol and cannabidiol as potential curative agents for cancer: A critical examination of the preclinical literature. 2015

Use and medicalization of marihuana in cancer patients. 2014

Therapeutic potential of cannabinoids in counteracting chemotherapy-induced adverse effects: an exploratory review.   2015

Medical marijuana for cancer. 2015

Use and medicalization of marihuana in cancer patients. 2014

Cannabinoids as therapeutic agents in cancer: current status and future implications. 2014

Patterns of use of medical cannabis among Israeli cancer patients: a single institution experience. 2015

Complementary and alternative medicine for cancer pain: an overview of systematic reviews. 2014

Cancer pain and current theory for pain control. 2014

Is the clinical use of cannabis by oncology patients advisable? 2014

Management of cancer pain: 1. Wider implications of orthodox analgesics. 2014

Critical appraisal of the potential use of cannabinoids in cancer management. 2013

Therapeutic potential of cannabinoid medicines. 2014

Can medical herbs stimulate regeneration or neuroprotection and treat neuropathic pain in chemotherapy-induced peripheral neuropathy? 2013

The medical necessity for medicinal cannabis: prospective, observational study evaluating the treatment in cancer patients on supportive or palliative care. 2013

The pharmacologic and clinical effects of medical cannabis. 2013

CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells. 2012

Novel Δ(9) -tetrahydrocannabinol formulation Namisol® has beneficial pharmacokinetics and promising pharmacodynamic effects. 2012

Cannabinoid-associated cell death mechanisms in tumor models (review). 2012

Cannabidiol in humans-the quest for therapeutic targets. 2012

Evaluation of the cyclooxygenase inhibiting effects of six major cannabinoids isolated from Cannabis sativa. 2011

Cannabis in palliative medicine: improving care and reducing opioid-related morbidity. 2011

The endocannabinoid system and cancer: therapeutic implication. 2011

Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. 2011

Commentary on Green AJ & De-Vries K (2010) Cannabis use in palliative care–an examination of the evidence and the implications for nurses. Journal of Clinical Nursing 19, 2454-2462. 2010

Cannabis use in palliative care – an examination of the evidence and the implications for nurses. 2010

Cannabis-derived substances in cancer therapy–an emerging anti-inflammatory role for the cannabinoids. 2010

FAAH and MAGL inhibitors: therapeutic opportunities from regulating endocannabinoid levels. 2010

Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. 2009

Endocannabinoid system: An overview of its potential in current medical practice. 2009

Cannabinoids in the treatment of cancer. 2009

Use of cannabinoid receptor agonists in cancer therapy as palliative and curative agents. 2009

Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action. 2008

Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8. 2008

The endocannabinoid system in cancer-potential therapeutic target? 2008

Medicinal cannabis in oncology. 2007

Cannabidiol–recent advances. 2007

History of cannabis and its preparations in saga, science, and sobriquet. 2007

Human studies of cannabinoids and medicinal cannabis. 2005

Cannabinoids in medicine: A review of their therapeutic potential. 2006

Cannabinoids and cancer: pros and cons of an antitumour strategy. 2006

The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. 2006

Antiestrogenic effects of marijuana smoke condensate and cannabinoid compounds. 2005

A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol. 2006

Cannabinoid receptor as a novel target for the treatment of prostate cancer. 2005

Cannabinoids and cancer: causation, remediation, and palliation. 2005

Synthesis and antitumor activity of quinonoid derivatives of cannabinoids. 2004

Cannabinoid receptor systems: therapeutic targets for tumour intervention. 2003

Cannabinoids: potential anticancer agents. 2003

[The endocannabinoid system as a target for the development of new drugs for cancer therapy]. 2003

Established and potential therapeutic applications of cannabinoids in oncology. 2003

Cannabis and cannabidiol: interview with Robert Gorter, M.D. Interview by Fred Gardner. 1998

Control of the cell survival/death decision by cannabinoids. 2001

Endocannabinoids and fatty acid amides in cancer, inflammation and related disorders. 2000

[Cannabis and cancer]. 2000

Endocannabinoids: new targets for drug development. 2000

Analysis of the medical use of marijuana and its societal implications. 1998

Cancer problems lead list for potential medical marijuana research studies. 1997

CBD for Pain

Cannabinoid Buccal Spray for Chronic Neuropathic Pain: A Review of Clinical Effectiveness, Safety, and Guidelines [Internet]. 2016
Systematic Review of the Use of Phytochemicals for Management of Pain in Cancer Therapy. 2015

Cannabis for the Management of Pain: Assessment of Safety Study (COMPASS). 2015

Do cannabinoids have a role in cancer pain management? 2009

Cannabinoids:their role in pain and palliation. 2007

Cannabis, pain, and sleep: lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine. 2007

Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review. 2001

CBD for Nausea

Dronabinol for chemotherapy-induced nausea and vomiting unresponsive to antiemetics.   2016

Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy. 2015

Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system. 2014

Therapeutic use of Cannabis sativa on chemotherapy-induced nausea and vomiting among cancer patients: systematic review and meta-analysis. 2008

 

CBD for Bone Cancer

Emerging therapeutic targets in cancer induced bone disease: A focus on the peripheral type 2 cannabinoid receptor.   2017

CBD for Brain Cancer

Quantitative Analyses of Synergistic Responses between Cannabidiol and DNA-Damaging Agents on the Proliferation and Viability of Glioblastoma and Neural Progenitor Cells in Culture. 2017

In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma. 2016

Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme. 2013

Spontaneous regression of septum pellucidum/forniceal pilocytic astrocytomas–possible role of Cannabis inhalation. 2011

Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas. 2010

Molecular mechanisms involved in the antitumor activity of cannabinoids on gliomas: role for oxidative stress. 2010

Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. 2008

Cannabinoids and gliomas. 2007

Targeting astrocytomas and invading immune cells with cannabinoids: a promising therapeutic avenue. 2007

Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells. 2008

Down-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity? 2008

Medicinal cannabis does not influence the clinical pharmacokinetics of irinotecan and docetaxel. 2007

Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (review). 2007

Hypothesis: cannabinoid therapy for the treatment of gliomas? 2004

 

CBD for Breast Cancer

Cannabidiolic acid-mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells: possible involvement of its down-regulation in the abrogation of aggressiveness.  2017

Δ(9)-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: possible involvement of induced levels of PPARα in MDA-MB-231 breast cancer cells.   2014

Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells. 2014

Cannabidiol enhances xenobiotic permeability through the human placental barrier by direct inhibition of breast cancer resistance protein: an ex vivo study. 2013

Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration. 2012

Cannabinoids: a new hope for breast cancer therapy? 2012

Enhanced brain disposition and effects of Δ9-tetrahydrocannabinol in P-glycoprotein and breast cancer resistance protein knockout mice. 2012

Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy. 2011

Modulation of Delta9-tetrahydrocannabinol-induced MCF-7 breast cancer cell growth by cyclooxygenase and aromatase. 2009

Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. 2006

CBD for Cachexia

Pharmacokinetics of Cannabis in Cancer Cachexia-Anorexia Syndrome. 2016

Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis-In-Cachexia-Study-Group. 2006

The cannabinoids: an overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection. 2001

Cancer cachexia and cannabinoids. 1999

CBD for Cervical Cancer

Cannabidiol rather than Cannabis sativa extracts inhibit cell growth and induce apoptosis in cervical cancer cells. 2016

Arachidonyl ethanolamide induces apoptosis of uterine cervix cancer cells via aberrantly expressed vanilloid receptor-1. 2004

CBD for Colon Cancer

GPR55 promotes migration and adhesion of colon cancer cells indicating a role in metastasis. 2016

Endocannabinoids and the Digestive Tract and Bladder in Health and Disease. 2015

The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids. 2015

Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol. 2014

Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid. 2014

Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer. 2012

Physiological intestinal oxygen modulates the Caco-2 cell model and increases sensitivity to the phytocannabinoid cannabidiol. 2014

Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent. 2011

Evaluation of the cyclooxygenase inhibiting effects of six major cannabinoids isolated from Cannabis sativa. 2011

A cannabinoid anticancer quinone, HU-331, is more potent and less cardiotoxic than doxorubicin: a comparative in vivo study. 2007

Phytomedicine Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol. 2015

CBD for Gastric Cancer

WIN 55,212-2 Inhibits the Epithelial Mesenchymal Transition of Gastric Cancer Cells via COX-2 Signals. 2016


CBD for Leukemia

(2013) Cannabis extract treatment for terminal acute lymphoblastic leukemia with a Philadelphia chromosome mutation.

(2008) Enhancing the in vitro cytotoxic activity of Delta9-tetrahydrocannabinol in leukemic cells through a combinatorial approach.

(2007) Cannabidiol, unlike synthetic cannabinoids, triggers activation of RBL-2H3 mast cells.

(2006) The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells.

(1993) Cannabinoid-receptor expression in human leukocytes.

(1972) Transformation of Fischer rat embryo cells by the combined action of murine leukemia virus and (-)-trans- 9 -tetrahydrocannabinol.

CBD for Liver Cancer

PPARγ mediates the effects of WIN55,212-2, an synthetic cannabinoid, on the proliferation and apoptosis of the BEL-7402 hepatocarcinoma cells. 2013

Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy. 2011

CBD for Lung Cancer

(2014) Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1.

(2014) Cannabinoids inhibit angiogenic capacities of endothelial cells via release of tissue inhibitor of matrix metalloproteinases-1 from lung cancer cells.

(2013) COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells.

(2012) Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1.

(2010) Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells.

CBD for Oral Cancer

Review of Various Herbal Supplements as Complementary Treatments for Oral Cancer. 2016

Concomitant consumption of marijuana, alcohol and tobacco in oral squamous cell carcinoma development and progression: recent advances and challenges. 2012

 

CBD for Prostate Cancer

Towards the use of non-psychoactive cannabinoids for prostate cancer. 2013

Proapoptotic effect of endocannabinoids in prostate cancer cells. 2015

Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms. 2013

The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications. 2012

CBD for Skin Cancer

Medical marijuana use in head and neck squamous cell carcinoma patients treated with radiotherapy. 2016

CBD for Thyroid Cancer

Repositioning therapy for thyroid cancer: new insights on established medications. 2014

A metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosis. 2010