Research on CBD for Pain

2017 Sleep disturbances and severe stress as glial activators: key targets for treating central sensitization in chronic pain patients?

2017 Cannabidiol Is a Potential Therapeutic for the Affective-Motivational Dimension of Incision Pain in Rats.

2017 Cannabis and intractable chronic pain: an explorative retrospective analysis of Italian cohort of 614 patients.

2017 Single and combined effects of Δ9 -tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy-induced neuropathic pain.

2017 Cannabidiol-Δ9-tetrahydrocannabinol interactions on acute pain and locomotor activity.

2016 A user’s guide to cannabinoid therapies in oncology.

2016 Evolution of multiple sclerosis spasticity-associated symptoms: latest data.

2016 Cannabinoid Buccal Spray for Chronic Non-Cancer or Neuropathic Pain: A Review of Clinical Effectiveness, Safety, and Guidelines.

2016 Tetrahydrocannabinol:Cannabidiol Oromucosal Spray for Multiple Sclerosis-Related Resistant Spasticity in Daily Practice.

2016Refractory trigeminal neuralgia responsive to nabiximols in a patient with multiple sclerosis.

2016 Cannabinoids for Symptom Management and Cancer Therapy: The Evidence.

2016 The Use of Medical Marijuana in Cancer.

2016 Effects of Delta-9-Tetrahydrocannabinol and Cannabidiol on Cisplatin-Induced Neuropathy in Mice.

2016 Efficacy, tolerability and safety of cannabinoids for chronic neuropathic pain: A systematic review of randomized controlled studies.

2016 Efficacy, tolerability and safety of cannabinoids in chronic pain associated with rheumatic diseases (fibromyalgia syndrome, back pain, osteoarthritis, rheumatoid arthritis): A systematic review of randomized controlled trials.

2016 Use of Cannabinoids for Spasticity and Pain Management in MS.

2016 Long-Term Data of Efficacy, Safety, and Tolerability in a Real-Life Setting of THC/CBD Oromucosal Spray-Treated Multiple Sclerosis Patients.

2016 Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis.

2015 Medical Marijuana and Chronic Pain: a Review of Basic Science and Clinical Evidence.

2015 Clinical pharmacology of medical cannabinoids in chronic pain.

2015 Assessment of the effectiveness and safety of Sativex® in compassionate use.

2015 The effectiveness of cannabinoids in the management of chronic nonmalignant neuropathic pain: a systematic review.

2015 Distinct interactions of cannabidiol and morphine in three nociceptive behavioral models in mice.

2014 Cannabidiol and endogenous opioid peptide-mediated mechanisms modulate antinociception induced by transcutaneous electrostimulation of the peripheral nervous system.

2015 A multicentre, open-label, follow-on study to assess the long-term maintenance of effect, tolerance and safety of THC/CBD oromucosal spray in the management of neuropathic pain.

2014 A double-blind, randomized, placebo-controlled, parallel group study of THC/CBD spray in peripheral neuropathic pain treatment.

2013 The endocannabinoid system, cannabinoids, and pain.

2014 Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT(1A) receptors without diminishing nervous system function or chemotherapy efficacy.

2014 A double-blind, placebo-controlled, crossover pilot trial with extension using an oral mucosal cannabinoid extract for treatment of chemotherapy-induced neuropathic pain.

2013 Pharmacokinetic evaluation of nabiximols for the treatment of multiple sclerosis pain.

2013 A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis.

2013 An open-label extension study to investigate the long-term safety and tolerability of THC/CBD oromucosal spray and oromucosal THC spray in patients with terminal cancer-related pain refractory to strong opioid analgesics.

2012 Nabiximols in the treatment of spasticity, pain and urinary symptoms due to multiple sclerosis.

2012 Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.

2012 Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial.

2011 Cannabidiol prevents the development of cold and mechanical allodynia in paclitaxel-treated female C57Bl6 mice.

2011 The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55.

2011 Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action.

2010 New guidelines for the treatment of neuropathic pain.

2010 Pharmacological characterization of GPR55, a putative cannabinoid receptor.

2010 Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain.

2010 Examining the roles of cannabinoids in pain and other therapeutic indications: a review.

2010 Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain.

2009 Standardized natural product cannabis in pain management and observations at a Canadian compassion society: a case report.

2010 Randomized placebo-controlled double-blind clinical trial of cannabis-based medicinal product (Sativex) in painful diabetic neuropathy: depression is a major confounding factor.

2009 Cannabinoids as pharmacotherapies for neuropathic pain: from the bench to the bedside.

2009 Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception.

2009 Willingness to pay for a treatment for pain in multiple sclerosis.

2009 Cannabinoids against pain. Efficacy and strategies to reduce psychoactivity: a clinical perspective.

2008 Cannabinoids in the management of difficult to treat pain.

2008 Pain relief with cannabinoids– the importance of endocannabinoids and cannabinoids for pain therapy].

2008 Antihyperalgesic effect of a Cannabis sativa extract in a rat model of neuropathic pain: mechanisms involved.

2006 Role of the cannabinoid system in pain control and therapeutic implications for the management of acute and chronic pain episodes.

2009 Cannabinoid-induced effects on the nociceptive system: a neurophysiological study in patients with secondary progressive multiple sclerosis.

2008 Managing neuropathic pain with Sativex: a review of its pros and cons.

2008 Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8.

2007 Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial.

2007 Sativex successfully treats neuropathic pain characterised by allodynia: a randomised, double-blind, placebo-controlled clinical trial.

2007 Cannabis, pain, and sleep: lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine.

2007 Update on pharmacotherapy guidelines for treatment of neuropathic pain.

2007 Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain.

2007 Latest pain relief a combination of new and old.

2007 New pain management options: drugs.

2007 The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain.

2006 The use of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis.

2006 Sativex: clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain.

2006 Cannabinoid analgesia as a potential new therapeutic option in the treatment of chronic pain.

2006 Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis.

2005 Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis.

2004 Pain reduction and lack of psychotropic effects with ajulemic acid: comment on the article by Sumariwalla et al.

2004 Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomised controlled trial.

2004 Initial experiences with medicinal extracts of cannabis for chronic pain: results from 34 ‘N of 1’ studies.

2004 Effects of coadministration of cannabinoids and morphine on nociceptive behaviour, brain monoamines and HPA axis activity in a rat model of persistent pain.

2003 Safety, tolerability, and efficacy of orally administered cannabinoids in MS.